methionine restriction glutathione and lifespan control Methionine Restriction and Cancer Biology

(350) Massey, L

During aging, mtNOS switches to uncoupled mode, that involved loss of the ability to convert L-arginine into L-citrulline with the release of NO, instead, it catalyzes a transfer of electrons from NADPH to molecular oxygen with the formation of a superoxide anion radical (Roe and Ren, 2012

Given its energetic requirements, it should be no surprise that researchers are increasingly making connections between the brain and mitochondrial health (mitochondria are power horse organelles found in most cells and are responsible for cellular respiration and energy production)

Korman TP

Atherosclerosis represents a state of intense oxidative stress characterized by vascular wall lipid and protein oxidation that contributes to chronic inflammation within the arterial wall, in which CRP is a major player (Figure 7)