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In addition, metformin could regulate DNA/histone modifications and miRNAs to carry out transcriptional regulatory processes (

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8 The limited range of symptom presentation makes it difficult to localize focal brain lesions

In recent years, a synthetic peptide called Dihexa has emerged as a promising cognitive enhancer for improving certain cognitive functions, cognitive enhancement, learning and long term memory capacity

Though useful for accounting for study endpoint events in a rapidly fatal disease (i.e., death versus study completion versus trial withdrawal), combined outcomes suffer from issues with cross-trial validity and weighting the importance of relative contributions to outcome (death versus disease progression versus loss of follow-up) in creating the summed rank model [51]