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Biochemically, they are cleared and/or metabolized by the liver
doi: 10.1021/ja010452r
DHODH-mediated ferroptosis defense is a targetable vulnerability in cancer
On the other hand a next-generation hypomethylating agent named guadecitabine (SGI-110) that is a dinucleotide of decitabine linked via a phosphodiester bond to deoxyguanosine has been characterized (Thottassery et al., 2014)
