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Combining RNA interference with hyaluronan-coated nanoparticles offers a promising strategy for treating glaucoma ( 2.1.7 Adenosine Adenosine is a ubiquitous local modulator that interacts with four membrane receptors: A1, A2A, A2B, and A3 to regulate various physiological and pathological processes ( Activation of A1 receptors in the ciliary body and TM reduces AH production and outflow resistance, lowering IOP ( Adenosine receptor signaling pathways involve molecular mechanisms such as adenylyl cyclase, phospholipase-inositol triphosphate-diacylglycerol, and phosphatidylinositol-3-kinase, which activate MAPK pathways that influence gene transcription ( Several clinical studies, including Phase 2 and 3 trials, have focused on evaluating the efficacy of various topical formulations in lowering IOP in adults with OHT or POAG, comparing them to existing therapies like latanoprost and timolol (NCT01917383, NCT02565173)

Supplementary information Supplementary Table 1 and uncropped western blots for Extended Data Fig

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Often, trigger points arise following stress on the muscle fibers from acute trauma or repetitive microtrauma