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It is a strategy now used in several approved drugs (semaglutide, for example, achieves its once-weekly dosing through fatty acid-mediated albumin binding)
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J Biol Chem 281(9):56575667
AMP-activated protein kinase (AMPK) works through peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) to promote mitochondrial biogenesis
