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First, we constructed lentivirus containing cytosolic located TpNOX (Lv-TpNOX) and infected primary cultured HAECs for 2 days

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Reschke L., Afrin S., El Sabah M., Charewycz N., Miyashita-Ishiwata M., Borahay M.A

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Microtubular structure plays a key role in myelination, neuronal cytoskeletal junction, and cell-matrix attachment and has a dramatic effect on brain stiffness ( Molecular hydrogen is a new type of antioxidant with potent free radical scavenging ability, and its exertion of biological effects may also result from its extensive influence on metabolic pathways ( GSH plays a vital role in the neuronal antioxidant defense system and in maintenance of neuronal redox homeostasis

The specificity and effective in vivo concentrations of many natural products or small molecule agonists are debatable, with some effects possibly stemming from their broad-spectrum antioxidant capacity rather than genuine Nrf2-specific action