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There can be an immediate solution, along with its modulatory controlling effect described above for VEGF (see above, Section 2.3 and Section 2.4), as the promoter of the egr-1 gene also mediates angiogenesis [158,159] and induces cytokine and growth factor generation and early extracellular matrix (collagen) formation

We mentioned it before, but it bears repeating

Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)

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