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Competitive cell proliferation assays To assess the effect of CRISPR/ Cas9 -mediated gene targeting on cell proliferation, Cas9 -expressing cells were transduced with sgRNA/IRFP670 expression vectors and IRFP670-positive cells were monitored at regular intervals by flow cytometry using an IntelliCyt IQueScreener Plus (BioScience, Sartorius Group, Germany)

Rosmarinic acid which is isolated from Salvia officinalis attenuates many processes proved by reactive oxygen species, lipid peroxidation, DNA fragmentation, Caspase 3 activation and Tau protein hyperphosphorylation

2016;6 doi: 10.1038/srep36903

Some common critical quality attributes of ADC drugs are listed in Table 3

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