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While inhibition of xCT suppresses cystine uptake and induces ferroptosis, we identified -glutamylcyclotransferase (GGCT), a key enzyme in glutathione (GSH) degradation, as a metabolic compensation pathway that regenerates cysteine to sustain redox homeostasis

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This review comprehensively elucidates the regulatory networks of ferroptosis in OS, with a specific focus on the System Xc/Glutathione Peroxidase 4 (GPX4) antioxidant axis and lipid metabolism

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