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doi: 10.1007/s11064-007-9315-z
Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells
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The reactive chemical 4-HNE is known to bind and form adducts to macromolecules including DNA [80], and cell culture studies demonstrate that Nrf2 and glutathione are needed to protect cells from 4-HNE and lipid peroxidation toxicity [81]
