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Cumulative Effects : Long-term research has not identified significant cumulative toxicity with aod 9604 peptides when used within established dosing guidelines

The FDA is set to render its decision on patisiran in ATTR-CM on or before Oct
Death is usually due to paralysis of the medullary centers
Dose reductions will usually get smaller as the dose decreases

doi: 10.1038/s41568-021-00365-x 389 FengYZhangZZhangHGuoHTanCXuNet al