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Given that a variety of cells in the lymph nodes possess the ability to express PD-L1, including LECs (215), dendritic cells (203), macrophages, B cells, T cells, and NK cells (204, 208, 209), understanding the impact of PD-1/PD-L1 immune checkpoint blockade on these cells and their interactions with T cells in the TDLNs might provide novel solutions to further enhance the efficacy of immunotherapy

NF-B has been described as a master regulator of inflammation since it regulates the expression of multiple inflammatory genes

Data has shown that Semax administration improves learning in animals and increases BDNF expression and expression of its high-affinity TrkB receptors in the rat hippocampus