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In this context, SIN has been shown to be capable of crossing the BBB (97, 144, 147), but its concentration in the brain is typically low

Tumor necrosis factor-, interleukin-1, and interferon- stimulate -secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

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The reason behind this finding might be accounted for the decreased NAPDH oxidase-dependent ROS generation resulting from decreased NADPH generation

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