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The chromosome 9p21.3 region is deleted in approximately 15% of cancers (3, 4) and contains the tumour suppressor gene cyclin-dependent kinase inhibitor 2A (CDKN2A)
Therefore, we tested Cyclin D1 in our cancer cell model
If the assay were measuring TNF bound to endogenous anti-TNF antibodies then infliximab, which binds to individual TNF subunits, should deplete the assay signal ( Figure 7C )
We next confirmed the production and secretion of several hepatic proteins
