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Low levels of vitamin D and folate increase the numbers of respiratory tract infections, asthma exacerbations, and allergy symptoms

H.ZhuX.et al (2012)

Detailed mechanism [edit] Two aspartate amino acid residues (below left) are interacting with two adjacent water molecules (w6 and w8) in the Mn 2+ isocitrate porcine IDH complex to deprotonate the alcohol off the alpha-carbon atom

This is in part due to the interactions with oncogenes

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