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As such, liver disease may lead to increased ROS production and, subsequently, increased peroxidation of lipid membranes and inflammatory factors production, leading to hepatocyte injury and cell death (6063)

doi: 10.1530/joe-12-0204 7 KhrleJJakobFContemprBDumontJE

These organ cross-talk mechanisms and the indirect effects of ALC via the improvement of liver and skeletal muscle metabolism, and thus the overall metabolism, might also explain the differences observed among trials and help the design of future studies by using objective measures of outcome and mechanisms of action of ALC

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