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Positioned downstream of PGC-1, a pivotal regulator coordinating mtDNA and nuclear DNA, Nrf1/2 serves as the primary initiator of mitochondrial biogenesis
doi: 10.1007/s10517-008-0121-7
Moreover, previous studies showed that different p53 mutations may have distinct oncogenic properties, and these mutations may promote tumour development beyond the LOF effect
In contrast, oral supplements depend on digestion, which can significantly lower the amount of nutrients absorbed [3] [4]
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