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In addition, the binding of HSC70 to clathrin-operating enzyme (cyclin G-associated kinase) has been demonstrated to be the key milestone in the regulation of clathrin-mediated endocytosis ( Extracellular signaling Even though mostly executing their functions intracellularly, there is a substantial portion of extracellular HSP70s released in endolysosomes, together with such proteins as cathepsin D and LAMP1 with the help of ATP-binding cassette transporters (Takeuchi et al., 2015) and microvesicles ( + T cells during the immune response ( Immune functions As among the most abundant intracellular proteins, HSP70s serve as signals of compromised cell integrity, namely, damage-associated molecular patterns (DAMPs), when released extracellularly (Soldatov et al., 2024