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The large, dimeric enzyme operates through a FAD cofactor and two essential cysteines, one of which is proximal to the glutathione disulfide docking site and the other to the FAD cofactor [129]
OH) ( The Glutamate Hypothesis Initially proposed in 1980 after glutamate levels were seen to be lower in the cerebrospinal fluid of schizophrenia patients ( A number of genes have been seen to influence the function of glutamate receptors ( 3 GRM 3 and SLC 3 8A 7 were directly correlated with combined glutamate and glutamine signal in the grey matter of younger schizophrenia patients ( 3.0.CO;2-B 109

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Li X., Hou P., Ma W., Wang X., Wang H., Yu Z., Chang H., Wang T., Jin S., Wang X., et al

These dual biochemical effects make it a focal point for research on metabolic reprogramming and longevity
