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A different study found a significant reduction in pore size via a dermatoscopic analyzer after 60 women applied tretinoin 0.025% cream once daily for 90 days.[28] While the direct relationship between pore size and sebum production makes this interesting, one cannot conclude that topical retinoids decrease sebum production given that studies have not distinctly uncoupled this association

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Fatouros IG, Douroudos I, Panagoutsos S et al Effects of L-carnitine on oxidative stress responses in patients with renal disease