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Regulatory challenges are significant as well, with guidelines for EV-based therapeutics still under development

28 By activating p53, the liver initiates processes that promote cell cycle arrest, DNA repair, and apoptosis in damaged cells, 29 helping to limit the extent of liver injury and facilitating the removal of cells that have sustained significant damage

The short-term efficacy of combined treatments targeting B cell and plasma cell in severe and refractory Anti-N-methyl-D-aspartate receptor encephalitis: Two case reports

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Livers 14 were stopped due to features of progressive organ failure (severe lactic acidosis, increasing vascular resistance, and parenchymal changes), whereas Livers 59 were stopped following meeting our perfusion time targets (initially 120 h, extended to 144 h and 168 h)