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Our findings are agreement with studies that demonstrated that chronic METH treatment in rats (4 mg/kg, IP, 2 weeks) resulted in decreased CREB/pCREB immunostaining in the neuronal nuclei of striatum 60 and decreased pCREB expression in METH-treated cultured primary cortical neurons 61
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The process is slow but steady, taking a few weeks to be evident, but the results are permanent
