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47-49 SARS CoV-2 disturbs the coordination between remethylation and transsulfuration reaction through S-adenosyl methionine (SAM), 50,51 SAM inhibits 5, 10-methylene, THF reductase (MTHFR) and activates cystathionine beta synthase (CBS), this reaction affords a mechanism by which re-methylation and transsulfuration are coordinated

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