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Taken together, the available evidence indicates that Pb-induced EAAT dysfunction is likely to be multifactorial, involving oxidative stress, impaired calcium and energy homeostasis, altered neurotrophic support, disrupted neuronglia communication, and inflammation
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Overexpression of SIRT7-WT, but not the catalytically inactive SIRT7-H187Y ( Homo sapiens )/H188Y ( Mus musculus ) mutants 27 , restored contractile marker expression in PDGF-BB-treated VSMCs (Supplementary Fig
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