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This process could be induced by transactivation of the gene encoding pyruvate dehydrogenase kinase 1 ( PDK1 ) by HIF-1, thus reducing the amount of pyruvate entering the TCA cycle [100]

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Moreover, in the osteoblast-specific knockout of igf-1r , PTH administration in vivo was unable to increase osteoprogenitor number in vitro (Wang et al., 2007)

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