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Endothelial NOS (eNOS) is constitutively expressed mainly in endothelial cells, whereas the expression of inducible NOS (iNOS) can be stimulated by diverse factors such as cytokines and endotoxin in different circumstances

Constitutive and -naphthoflavone-induced expression of the human -glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

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In addition to this, many people have problems metabolizing B12 in low-quality forms like cyanocobalamin due to defects in the MTHFR gene (1) (as many as 40% of people have THIS problem!)

Loft S, Olsen A, Mller P, Poulsen HE, Tjnneland A (2013) Association between 8-oxo-7,8-dihydro-2-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study