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The activation of microglia and astrocytes under inflammatory conditions in mouse models of Parkinsons disease is region-dependent, especially in the striatum and midbrain ( Inflammatory reactions can also lead to oxidative stress, that is, excessive production of oxygen free radicals in cells, which exceeds the ability of cells to scavenge

Abbreviations ALL: acute lymphoblastic leukemia AML: acute myeloid leukemia BCSC: breast cancer stem cell BM: bone marrow COVID-19: coronavirus disease 2019 CPT1: carnitinepalmitoyl transferase 1 CRS: cytokine release syndrome CRU: competitive repopulating unit CSC: cancer stem cell EC: endothelial cell EIF: eukaryotic initiation factor ERK: extracellular regulated MAP kinase FAO: fatty acid oxidation FGSEA: fast gene set enrichment analysis G-CSF: granulocyte colony stimulating factor GFP: green fluorescence protein GM-CSF: granulocyte-macrophage colony-stimulating factor HCT: hematopoietic cell transplant HPC: hematopoietic progenitor cell HSC: hematopoietic stem cell IFN: interferon IL: interleukin iPSC: induced pluripotent stem cell JAK/STAT: Janus kinase-signal transducer and activator of transcription LEP: leptin LEPR: leptin receptor LIF: leukemia inhibitory factor LSK: Lineage(Lin) Sca1 + cKit + LT: long-term MDS: myeloid dysplastic syndrome MEK: Mitogen-activated protein kinase kinase MI: myocardial infarction MPP: multipotent progenitor MSC: mesenchymal stem cell NF-B: nuclear factor kappa b PDGFR: platelet-derived growth factor receptor alpha PMF: primary myelofibrosis PRDM1: PR domain containing 1 PTN: pleiotrophin RAPTOR: regulatory associated protein of mTOR SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 SCF: stem cell factor SGLT1: sodium-glucose symporter 1 TNBC: triple negative breast cancer cell TNF: tumor necrosis factor TPO: thrombopoietin Treg: regulatory T VE-cad: vascular endothelial cadherin WT: wild-type XBP1: X-box binding protein 1 References Bahary, N., Leibel, R

Statements Data availability statement All data are available upon reasonable request from the corresponding author

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On the other hand, theres also a risk associated with the loss of a highly skilled manager, commonly referred to as key man risk