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B12 and MTHFR: Understanding the Connection and Its Impact on Health October 29, 2024|Blog The relationship between Vitamin B12 and the MTHFR gene mutation has been increasingly discussed in the world of functional medicine and health optimization

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If the vitamin B12 is ingested in its protein bound form, then it must first undergo a proteolytic cleavage in the stomach or duodenum where it will bind to an R-binder and then enter into the duodenum for further cleavage.1,2,8 This proteolytic cleavage is mostly dependent on the functional activity of pepsin

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