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Muscle-strengthening program This HLST muscle-strengthening program was initially proposed by Rathleff and colleagues, 9 and encompasses concentric and eccentric heel-raise exercises designed to treat PF

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The mechanisms are well-characterized: angiogenesis, collagen synthesis, inflammation reduction, and neuroprotection

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In fact, the benefits of MOTS-c on the heart were likened to those of aerobic exercise improving cardiac energy metabolism, reducing pathological remodeling, and enhancing angiogenesis (formation of new blood vessels) in cardiac tissue