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Flavonoids Flavonoids are natural substances mainly present in fruits and vegetables (He et al., 2017) that have a protective effect against ROS (Cao et al., 1997), modulate the activity of different metabolic pathways (Mansuri et al., 2014) (Table 1) related to the reduction of cognitive damage and neuronal dysfunction (Vauzour et al., 2008) and suppress neuroinflammation (Solanki et al., 2015)

J.RoseS.MelnykS.JerniganS.BlossomS.PavlivO.et al

2019;11: eaay2602

When activated, Nrf2 dissociates from the cytosolic protein, Keap1 (Kelch-like ECH associated protein 1), and translocates to the nucleus to bind to AREs in the promoter/enhancer portion of genes associated with phase II detoxification and antioxidant enzyme genes [150] (Figure 1)

Morphological classification of biliary disorders of the canine and feline liver