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Checkmate459, a randomized phase III clinical test comparing nivolumab and sorafenib in first-line HCC therapy, failed to meet its primary endpoint, which clearly emphasized the urgent need for patient selection 36

Through these reactions as well as its interactions with a number of proteins, glutathione is one of the major regulators of cancer cell development, progression, response to therapy and its environment leading to a number of avenues for therapeutic targeting (Figure 1)

10.1016/S0002-9440(10)63877-1 4 BaiT.LiangB.ZhaoY.HanJ.PuY.WangC.et al (2022)

Mechanisms of oxidative stress-induced sperm dysfunction

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