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Key measured outcomes in that trial format include: percent change in body weight over the protocol window waist circumference and other anthropometric measures adverse events and discontinuations These are the exact measurements that make the literature readable and non vague

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Limitations include the restricted choices of E3 ligases, primarily CRBN and VHL, and the considerable molecular weight of compounds that cause poor BBB penetration

Some BPC-157 studies have reported increased endothelial tube-formation parameters or VEGFR2-associated readouts in selected experimental systems