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The results showed that EODF significantly reduced hippocampal CA3 region neuronal loss, and Morris water maze tests (latency, exploration trials) showed significant differences between the EODF and AL groups, suggesting that 23 months of EODF could significantly reduce kainic acid-induced hippocampal damage and visuospatial memory impairment

Interestingly, transcript levels of the 1 subunit are decreased in the proximal peri-infarct cortical area 7 days after photothrombosis (Kharlamov et al., 2008)

As Gpx4 / mice exhibit early embryonic lethality (40), multiple chemical compounds, targeting either GPX4 or other regulators of ferroptosis, are broadly used to elucidate the role of ferroptosis in multiple disorders (41)

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Ko WC, Lei CB, Lin YL, Chen CF