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The FDA-approved prescribing information for tirzepatide includes a warning about acute pancreatitis, consistent with labeling for other GLP-1 receptor agonists, but this reflects precautionary monitoring rather than confirmed causation

Its antioxidant role protects cells, including nerve cells from oxidative damage

As the causative bacteria die off due to antibiotics, inflammatory agents are released and temporarily worsen symptoms before improvement is noted

doi: 10.1016/j.bcmd.2011.10.001

In addition, there may be supratentorial, infratentorial, and cortical vasogenic edema, with cerebellar, brainstem and thalamic involvement in about 1/3 of patients [66, 67]