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Some of the most serious complications associated with pregnancy, such as preeclampsia, FGR, or gestational diabetes mellitus (GDM), show an increase in parameters of inflammation and OS in both the mother and the foetus [9], as well as lower antioxidant status and endogenous antioxidants

Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability

doi: 10.1038/s41590-021-01090-1

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they are short chains of amino acids that play different roles in the body