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Likewise, multifunctional nanomedicine platforms designed to induce ferroptosis, such as DHA-loaded Fe 3+ -doped MnO 2 nanosheets, may trigger excessive ROS generation and glutathione depletion beyond the tumor boundary, potentially leading to systemic inflammation, immune dysfunction, and off-target toxicity that could compromise patient safety
bioRxiv 669325 (2019)
[PubMed: 16596357] 889
And if you do have a condition that significantly inhibits your ability to absorb B12, like pernicious anemia, you likely need injected B12 supplements
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