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To avoid major differences in tumor size from the treatments, we treated tumor-bearing mice for just 5 days with either vehicle or rapamycin, prior to harvesting tumors for immunoblot analysis and metabolite profiling

We find that disrupting Fe-S cluster synthesis under cysteine restriction protects against the induction of ferroptosis, suggesting that the preservation of mitochondrial function is antagonistic to survival under starved conditions

Some research suggests immunomodulatory effects with potential to enhance immune functions that decline with aging

[DOI] [PubMed] [Google Scholar] 322.Dejardin E., Droin N.M., Delhase M., Haas E., Cao Y., Makris C., Li Z.-W., Karin M., Ware C.F., Green D.R

The role of TrxRs in ferroptosis is not clear