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Not surprisingly, this is also a place where whales aggregate
MTHFR variants can reduce methylfolate production, which affects the methylation cycle and SAMe availability
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Further support for an Igf-1r-mediated effect of Igf-2-signalling in this context comes from the finding that loss of Pten (Phosphatase and Tensin homolog) opposes the effect of Pals-1-deficiency: Pten-deficient mice have hyperplasic cortices while Pals-1-deficiency results in cortical hypoplasia
