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Food and Drug Administration has approved MTX652, a peripherally-restricted USP30 inhibitor, to enter a phase II clinical trial to treat acute kidney injury following cardiac surgery

10.1691/ph.2021.1684 3 AdetunjiJ

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Telomerase re-extends telomeres, but under conditions of oxidative stress, it shuttles from the nucleus to the mitochondria 62,63,64 , where it protects mitochondria biogenesis and decreases oxidative stress, partly by potentiating cellular antioxidant defense systems, such as by increasing the ratio of reduced (GSH) to oxidized (GSSG) glutathione 65 that is catalyzed by GPx and glutathione reductase activities

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