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In this work, by noting that pre-equilibration of ligand-receptor and ternary complex formation occur faster than the receptor internalization and downregulation, we formulate a minimal kinetic model to offer a semi-quantitative yet predictive understanding of the GPCR desensitization and down-regulation

History should be obtained to elicit the dose, the pattern of use, the time of the ingestion, the presence of coingestants, and the existence of comorbid conditions that may predispose to the development of hepatic injury

Glucose enters the axon via GLUT3 transporters, where it is converted into pyruvate in the cytoplasm

Nunes JC, Torres AG