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These symptoms are frequently severe enough to reinforce the person in recovery to start over the use of drug again and hinder the clinical use of drugs like morphine for chronic pain

doi:10.1016/j.sleep.2019.01.022

found that GBM cells with high Nrf2 expression were more resistant to temozolomide chemotherapy

XuYXiaoYLagnikaCLiDLiuCJiangNet al

To address these gaps, this review systematically synthesized contemporary knowledge, predominantly from the last decade, on the molecular mechanisms, risk factors, diagnostic frameworks, and therapeutic modalities for chronic pain, framed by its pathophysiological subtypes