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medRxiv 2020: 2020.2010.2007.20208702

This is supported by findings that albuminuria develops concurrently with cerebral dysfunction ( Under the conditions of DKD, renal dysfunction leads to an increase in the concentration of nitric oxide inhibitors, disrupting the integrity of the BBB, which in turn contributes to cerebral vascular endothelium injury and cognitive impairment (95)

For example, miR-23a inhibits autophagy to promote senescence but also protects from DNA damage and apoptosis, highlighting a dual cytoprotective role 109