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However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]
FIGURE 1 This synthesis protocol leverages the coupling reaction of FA with graphene oxide through a phenylboronic acid derivative, an approach similar to that described by Li et al
This results in reduced Akt activation and uncontrolled GSK3 activity
Further, selenium supplementation trials (whether with ASD cohorts or others) lack clear definitions of the type of selenium used for supplementation
