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Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, Nadler JL

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Beyond passive polymer barriers, quaternary ammonium chitosan was found to reduce the infectivity of SARS-CoV-2 owing to its mucoadhesive properties, chemical stability and electrostatic binding to the viral spike proteins 28

Occludin, claudin, and zonula occludens-1 (ZO-1) are intercellular junction proteins, essential for maintaining BRB integrity, and the breakdown of the BRB is closely linked to the dysfunction of these junction-associated proteins