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Description

Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc 1 complex

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Although the mitochondrial electron transport chain (ETC) is a highly efficient system, approximately 2% of electrons may leak from the ETC and react with molecular oxygen to form the superoxide anion radical (O 2 )

Lamotrigine prevented the toxicity caused by rotenone and MPP + in rat PC12 cells by suppressing the MPT formation, which leads to cytochrome release and subsequent apoptosis