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Their transient knockdown, except CoQ8 and CoQ6 , reduced CoQ 10 levels, but just CoQ7 knockdown could hamper mitochondrial respiration and elevated ubiquinol to ubiquinone ratios and also cause the accumulation of a putative biosynthetic intermediate characterized by reversible redox property, like CoQ 10 (Yen et al., 2016)

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The question of aging is is beyond the scope of this manuscript, and we refer the reader to some notable studies on the histology (Gao and Hollyfield, 1992

History of surgical debridement, anticentromere antibody, and disease duration are associated with calcinosis in patients with systemic sclerosis

Journal of Laboratory and Clinical Medicine