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For example, in HEK293 cells, oxymetazoline induced GRK2-mediated phosphorylation of 1A -ARs, which resulted in a much faster desensitization and internalization rate than that with noradrenaline-activated 1A -ARs, which were phosphorylated by PKC
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The selected subjects had a mean weight, as follows: Group I, 79.5017.9 kg
10.1021/bi0015818 180 TanY.-Q.LiJ.ChenH.-W
doi: 10.1038/nchembio.2261 28 DixonS
