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Nadkarni GN, Chauhan K, Rao V, Ix JH, Shlipak MG, Parikh CR, et al

Blocking GSH synthesis in combination with JMF4073 depletes dTTP/dCTP pools to eradicate T315I-Bcr-Abl leukemia We hypothesize that reducing the GSH level to increase replication stress can render T315I-Bcr-Abl leukemia more susceptible to JMF4073 in vivo

CAFs are stromal cells within the tumor microenvironment that exhibit diverse biological characteristics, often demonstrating tumor-promoting activity

The study was conducted throughout Ramadan, including roughly 17 h of daily fasting from dawn to sunset during a 29-day period

The standard steps are to calculate the dose-response curve (the pharmacological effect of a drug on the body for different doses) and the time-effect curve (at the same dose, the pharmacological effect of the drug on the body for different times)