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Description
Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function
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J Eur Acad Dermatol Venereol 21:7984 Obara K, Ishihara M, Fujita M, Kanatani Y, Hattori H, Matsui T et al (2005) Acceleration of wound healing in healing-impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2
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doi: 10.1126/science.abd4585 93 SudreCHMurrayBVarsavskyTGrahamMSPenfoldRSBowyerRCet al
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Glycine residues provide flexibility for enzyme active sites
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