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Antioxid Redox Signal 15:817829

elegans lacking the ads-1 gene, encoding AGPS, or human HT-1080 cells treated with an AGPS inhibitor showed increased lipid peroxidation and ferroptosis rates 139

10.1016/0140-6736(91)90350-x [DOI] [PubMed] [Google Scholar] 132.Prousky J

While the clinical evaluation of GLP-1MK-801 for weight loss awaits, efforts to broaden the scope of developing peptide-mediated targeting of ion channels are encouraged and should not be restricted to metabolic diseases

This effect is partly mediated through the modulation of key cell cycle regulators such as cyclin D1 and p21, which facilitates progression from the G1 to S phase